Image for papers



White Paper - Analgesic Agents and Strategies in Pain Research - August 2015
Model: Dental Pain
Stefano Milleri, Crispin Bennet
“Assessment of the pharmacokinetic profile of the newer formulations of Enterogermina® ampoules 4x109 and powder sachets 6x109 spores for once daily administration" Antonio Gasbarrini1, Pierangelo Geppetti, Stefano Milleri, Lorenzo Morelli
“Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain”. J Headache Pain. 2015 Dec; Epub 2015 Jun 27
Model: Dental Pain
Moore R.A., Gay-Escoda C., Figueiredo R., Tóth-Bagi Z, Dietrich T, Milleri S, et al.
White Paper - Early Phase Clinical Research in Italy - November 2014
Cristina Costantin
Alprazolam and the neurokinin-1 receptor antagonist GW 597599 attenuate the anxiogenic effects of 7% carbon dyoxide (CO2) challenge in healthy volunteers selected for their enhanced panic-like response. 2013 Submitted to Journal of PSychopharmacology
Model: Co2 model
Stefano Zanone Poma, Emilio Merlo-Pich, Paolo Bettica, Massimo Bani, Paolo Fina, Luigi Ziviani, Stefano Milleri
“Safety, pharmacokinetic, and functional effects of the Nogo-A monoclonal antibody ozanezumab in amyotrophic lateral sclerosis: a randomised, placebo-controlled, dose-escalation study” 2013 Vincent Meininger MD, Stefano Milleri MD et al.
“Changes in neuroactive steroid secretion associated with CO2-induced panic attacks in normal individuals”. Psychoneuroendocrinology. 2013 May 20
Model: Co2 model
Brambilla F, Perini G, Serra M, Pisu MG, Zanone S, Toffanin T, Milleri S, Garcia CS, Biggio G.
A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction. Clin J Pain. 2011 May 2.
Model: Dental Pain
Ostenfeld T, Price J, Albanese M, Bullman J, Guillard F, Meyer I, Leeson R, Costantin C, Ziviani L, Nocini PF, Milleri S.
“The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double dummy, parallel group study”. Journal of Sexual Medicine, 2008 Apr
Model: Ejaculation model
Bruno Madeo, Paolo Bettica, Stefano Milleri, Antonio Balestrieri, Antonio RM Granata, Cesare Carani, Vincenzo Rochira
“Effect of bupropion sustained-release (SR) on craving, withdrawal and physiologic measures in smokers deprived of cigarettes for 72 hours”. Psychopharmacology, 183(1):1-12, 2005 Nov.
Model: 72 hours craving
Vincenzo Teneggi, Stephen T. Tiffany, Lisa Squassante, Stefano Milleri, Luigi Ziviani, Alan Bye
“Characterization of a 7% carbon dioxide (co2) inhalation paradigm to evoke anxiety symptoms in healthy subjects”. Journal of Psychopharmacology. 19(5):494-503, 2005 Sep.
Model: Co2 model
Stefano Zanone Poma, Stefano Milleri, Lisa Squassante, Gianluca Nucci, Massimo Bani, Giulia I. Perini and Emilio Merlo-Pich
“EEG power spectra and auditory P300 during free smoking and enforced smoking abstinence”. Pharmacology, Biochemistry and Behavior 77(1):103-9, 2004 Jan.
Model: EEG With Acoustic, Visual, Sensorial And Motor Evoked Potential
Vincenzo Teneggi, Luisa Squassante, Stefano Milleri, Alberto Polo, Paola Lanteri, Luigi Ziviani, Alan Bye
“Dose linearity of lacidipine pharmacokinetics after single and repeated oral doses in healthy volunteers”. Clinical Pharmacokinetics. 42(1): 99-106, 2003. Da Ros L., Squassante L., Milleri S
“Smokers deprived of cigarettes for 72h: effect of nicotine patches on craving and withdrawal”. Psychopharmacology 164: 177-187, 2002
Model: 72 hours craving
Teneggi V. Tiffany ST. Squassante L. Milleri S. Ziviani L. Bye A.
“Correlation and predictive performances of saliva and plasma nicotine concentration on tobacco withdrawal-induced craving”. Br. J. Clin. Pharmacology 54, 407–414, 2002.
Model: 72 hours craving
Teneggi V. Squassante L. Iavarone L. Milleri S. Bye A. Gomeni R
“Verifica della validità esteriore e del contenuto della versione italiana di tre questionari su craving e astinenza da fumo di sigarette” (“Assessment of face and content validity of the Italian version of three questionnaires on cigarette smoke craving and withdrawal”). Giornale Italiano Psicopatologia Vol 7, N4, 2001.
Model: 72 hours craving
Vincenzo Teneggi, Nadia Oprandi, Stefano Milleri, Lisa Squassante, Mauro Niero, Daniele Berto, Fabio Arpinelli, Alan Bye
“Salmeterol and fluticasone propionate given as a combination. Lack of systemic pharmacodynamic and pharmacokinetic interactions”. S.Kirby, C.Falcoz, M.J.Daniel, S.Milleri, L.Squassante, L.Ziviani, G.P.Ventresca
“Salmeterol and fluticasone propionate administered as a combination: lack of pharmacokinetic and pharmacodynamic interaction”. Eur. J. Clin. Pharmacology, 56, (11); 781-791, 2001 S. Kirby, S. Milleri, L. Squassante, G.P. Ventresca
“The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy volunteers”. Br. J. Clin. Pharmacology, 51 (2): 147-52, 2001 L. Ziviani, L. Da Ros, L. Squassante, S. Milleri, M. Cugola, L Iavarone
“Direct measurement of the anti-influenza agent zanamivir in the respiratory tract following inhaled administration”. Antimicrobial Agents and Chemotherapy 44(7): 1974-1976, 2000 Amy W. Peng, Stefano Milleri, Daniel S. Stein
“Evaluation of the readability of information sheets for healthy volunteers in phase-I trials”. Eur. J. Clin. Pharmacology; 56(5) Berto D. Peroni M. Milleri S. Spagnolo AG
“Enantiomeric disposition of inhaled, intravenous and oral (r,s)-albuterol in man - no evidence of enantioselective lung metabolism”. Br. J. Clin. Pharmacology, 49(1): 15-22, 2000 Jonathan Ward PhD, James Dow PhD, Nigel Dallow MSc, Paul Eynott BSc, Stefano Milleri MD and Pietro Ventresca MD
"Evaluation of personalty as a component of the healthy condition of volunteers participating in phase I studies". Eur. J. Clin. Pharmacology 51: 209-2013, 1996 D. Berto, S. Milleri, L. Squassante, P. Baroldi