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11 October 2023

Changes in bone turnover markers and bone modulators during abatacept treatment
Giovanni Adami, Giovanni Orsolini, Maurizio Rossini, Elisa Pedrollo, Anna Fratucello, Angelo Fassio, Ombretta Viapiana, Stefano Milleri, Elena Fracassi, Riccardo Bixio & Davide Gatti
June 2023

Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors
M.A. Deken, K. Niewola-Staszkowska, O. Peyruchaud, N. Mikulčić, M. Antolić, P. Shah, A. Cheasty, A. Tagliavini, A. Nizzardo, M. Pergher, L. Ziviani, S. Milleri, C. Pickering, M. Lahn, L. van der Veen, G. Di Conza, Z. Johnson
May 2023

GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomized placebo-controlled phase 2 trial.
Stefania Capone, Francesco M. Fusco, Stefano Milleri, Silvio Borrè, Sergio Carbonara, Sergio Lo Caputo, Sebastiano Leone, Giovanni Gori, Paolo Maggi, Antonio Cascio, Miriam Lichtner, Roberto Cauda, Sarah Dal Zoppo, Maria V. Cossu, Andrea Gori, Silvia Roda, Paola Confalonieri, Stefano Bonora, Gabriele Missale, Mauro Codeluppi, Ivano Mezzaroma, Serena Capici, Emanuele Pontali, Marco Libanore, Augusta Diani, Simone Lanini, Simone Battella, Alessandra M. Contino, Eva Piano Mortari, Francesco Genova, Gessica Parente, Rosella Dragonetti, Stefano Colloca, Luigi Visani, Claudio Iannacone, Rita Carsetti, Antonella Folgori, Roberto Camerini, COVITAR study group
December 2022

A first-in-human trial on the safety and immunogenicity of COVID-eVax, a cellular response-skewed DNA vaccine against COVID-19
Luigi Aurisicchio, Nadia Brambilla, Marina E. Cazzaniga, Paolo Bonfanti, Stefano Milleri, Paolo A. Ascierto, Serena Capici, Cristina Vitalini, Federica Girolami, Giampaolo Giacovelli, Gianfranco Caselli, Michela Visintin, Francesca Fanti, Matteo Ghirri, Antonella Conforti, Mirco Compagnone, Lucia Lione, Erika Salvatori, Eleonora Pinto, Alessia Muzi, Emanuele Marra, Fabio Palombo, Giuseppe Roscilli, Alessandro Manenti, Emanuele Montomoli, Matteo Cadossi, Lucio C. Rovati
November 2022

Effects on Serum Inflammatory Cytokines of Cholecalciferol Supplementation in Healthy Subjects with Vitamin D Deficiency.
Angelo Fassio, Davide Gatti, Maurizio Rossini, Davide Bertelle, Riccardo Bixio, Ombretta Viapiana, Stefano Milleri, Camilla Benini, Francesca Pistillo, Giulia Zanetti, Giovanni Adami
September 2022

Safety and immune response kinetics of GRAd-COV2 vaccine: phase 1 clinical trial results.
Chiara Agrati, Concetta Castilletti, Simone Battella, Eleonora Cimini, Giulia Matusali, Andrea Sommella, Alessandra Sacchi, Francesca Colavita, Alessandra M. Contino, Veronica Bordoni, Silvia Meschi, Giulia Gramigna, Federica Barra, Germana Grassi, Licia Bordi, Daniele Lapa, Stefania Notari, Rita Casetti, Aurora Bettini, Massimo Francalancia, Federica Ciufoli, Alessandra Vergori, Serena Vita, Michela Gentile, Angelo Raggioli, Maria M. Plazzi, Antonella Bacchieri, Emanuele Nicastri, Andrea Antinori, Stefano Milleri, Simone Lanini, Stefano Colloca, Enrico Girardi, Roberto Camerini, Giuseppe Ippolito, Francesco Vaia, Antonella Folgori and Stefania Capone
December 2021

Translating a novel autotaxin inhibitor from preclinical proof of concept in pancreatic cancer to a biomarker response in human subjects.
S.Milleri, MA.Deken, R.Medhi, A.Carruthers, A.Tagliavini, A.Nizzardo, M.Pergher, K.Niewola-Staszkowska, A.Cheasty, A.Fraser, P.Shah', L van der Veen, L.Ziviani, M.Lahn & Z.Johnson
October 2021

"GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults " Download:
38 authors, among them Stefano Milleri
August 2021

A single intramuscular injection of monoclonal antibody MAD0004J08 induces in healthy adults SARS-CoV-2 neutralising antibody titres exceeding those induced by infection and vaccination
22 authors, among them Stefano Milleri
July 2021

Pharmacodynamics of Oral Cholecalciferol in Healthy Individuals with Vitamin D Deficiency: A Randomized Open-Label Study.
Angelo Fassio, Davide Gatti, Maurizio Rossini, Camilla Benini, Elena Fracassi, Eugenia Bertoldo, Ombretta Viapiana, Stefano Milleri, Matteo Gatti, Giovanni Adami
July 2020

Recent Oncological Publications - Download
May 2020

Pharmacokinetics of Oral Cholecalciferol in Healthy Subjects with Vitamin D Deficiency: A Randomized Open-Label Study.
Angelo Fassio, Giovanni Adami, Maurizio Rossini, Alessandro Giollo, Cristian Caimmi, Riccardo Bixio, Ombretta Viapiana, Stefano Milleri, Matteo Gatti, Davide Gatti
“A Double-Blind, Placebo-Controlled Parallel Group Study to Evaluate the Effect of a Single Oral Dose of 5-HT1A Antagonist GSK958108 on Ejaculation Latency Time in Male Patients Suffering From Premature Ejaculation”. The Journal of Sexual Medicine, J Sex Med. 2021 Jan;18(1):63-71 Filippo Migliorini, MD, Alessandro Tafuri, MD, Paolo Bettica, MD, Luigi Ziviani, MD, Jesper Lund, MSc, Italo Poggesi, MD, Anna Marcer, MD, Giovanni E. Cacciamani, MD, Maria Fernanda Lorenzo-Gomez, MD, PhD, Antonio B. Porcaro, MD, Alessandro Antonelli, MD, and Stefano Milleri, MD
White Paper - Analgesic Agents and Strategies in Pain Research - August 2015
See model: Dental Pain
Stefano Milleri, Crispin Bennet
“Assessment of the pharmacokinetic profile of the newer formulations of Enterogermina® ampoules 4x109 and powder sachets 6x109 spores for once daily administration" Antonio Gasbarrini, Pierangelo Geppetti, Stefano Milleri, Lorenzo Morelli
“Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain”. J Headache Pain. 2015 Dec; Epub 2015 Jun 27
See model: Dental Pain
Moore R.A., Gay-Escoda C., Figueiredo R., Tóth-Bagi Z, Dietrich T, Milleri S, et al.
White Paper - Early Phase Clinical Research in Italy - November 2014
Cristina Costantin
Alprazolam and the neurokinin-1 receptor antagonist GW 597599 attenuate the anxiogenic effects of 7% carbon dyoxide (CO2) challenge in healthy volunteers selected for their enhanced panic-like response. 2013 Submitted to Journal of PSychopharmacology
See model: Co2 model
Stefano Zanone Poma, Emilio Merlo-Pich, Paolo Bettica, Massimo Bani, Paolo Fina, Luigi Ziviani, Stefano Milleri
“Safety, pharmacokinetic, and functional effects of the Nogo-A monoclonal antibody ozanezumab in amyotrophic lateral sclerosis: a randomised, placebo-controlled, dose-escalation study” 2013 Vincent Meininger MD, Stefano Milleri MD et al.
“Changes in neuroactive steroid secretion associated with CO2-induced panic attacks in normal individuals”. Psychoneuroendocrinology. 2013 May 20
See model: Co2 model
Brambilla F, Perini G, Serra M, Pisu MG, Zanone S, Toffanin T, Milleri S, Garcia CS, Biggio G.
A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction. Clin J Pain. 2011 May 2.
See model: Dental Pain
Ostenfeld T, Price J, Albanese M, Bullman J, Guillard F, Meyer I, Leeson R, Costantin C, Ziviani L, Nocini PF, Milleri S.
“The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double dummy, parallel group study”. Journal of Sexual Medicine, 2008 Apr
See model: Ejaculation model
Bruno Madeo, Paolo Bettica, Stefano Milleri, Antonio Balestrieri, Antonio RM Granata, Cesare Carani, Vincenzo Rochira
“Effect of bupropion sustained-release (SR) on craving, withdrawal and physiologic measures in smokers deprived of cigarettes for 72 hours”. Psychopharmacology, 183(1):1-12, 2005 Nov.
See model: 72 hours craving
Vincenzo Teneggi, Stephen T. Tiffany, Lisa Squassante, Stefano Milleri, Luigi Ziviani, Alan Bye
“Characterization of a 7% carbon dioxide (co2) inhalation paradigm to evoke anxiety symptoms in healthy subjects”. Journal of Psychopharmacology. 19(5):494-503, 2005 Sep.
See model: Co2 model
Stefano Zanone Poma, Stefano Milleri, Lisa Squassante, Gianluca Nucci, Massimo Bani, Giulia I. Perini and Emilio Merlo-Pich
“EEG power spectra and auditory P300 during free smoking and enforced smoking abstinence”. Pharmacology, Biochemistry and Behavior 77(1):103-9, 2004 Jan.
See model: EEG With Acoustic, Visual, Sensorial And Motor Evoked Potential
Vincenzo Teneggi, Luisa Squassante, Stefano Milleri, Alberto Polo, Paola Lanteri, Luigi Ziviani, Alan Bye
“Dose linearity of lacidipine pharmacokinetics after single and repeated oral doses in healthy volunteers”. Clinical Pharmacokinetics. 42(1): 99-106, 2003. Da Ros L., Squassante L., Milleri S
“Smokers deprived of cigarettes for 72h: effect of nicotine patches on craving and withdrawal”. Psychopharmacology 164: 177-187, 2002
See model: 72 hours craving
Teneggi V. Tiffany ST. Squassante L. Milleri S. Ziviani L. Bye A.
“Correlation and predictive performances of saliva and plasma nicotine concentration on tobacco withdrawal-induced craving”. Br. J. Clin. Pharmacology 54, 407–414, 2002.
See model: 72 hours craving
Teneggi V. Squassante L. Iavarone L. Milleri S. Bye A. Gomeni R
“Verifica della validità esteriore e del contenuto della versione italiana di tre questionari su craving e astinenza da fumo di sigarette” (“Assessment of face and content validity of the Italian version of three questionnaires on cigarette smoke craving and withdrawal”). Giornale Italiano Psicopatologia Vol 7, N4, 2001.
See model: 72 hours craving
Vincenzo Teneggi, Nadia Oprandi, Stefano Milleri, Lisa Squassante, Mauro Niero, Daniele Berto, Fabio Arpinelli, Alan Bye
“Salmeterol and fluticasone propionate given as a combination. Lack of systemic pharmacodynamic and pharmacokinetic interactions”. S.Kirby, C.Falcoz, M.J.Daniel, S.Milleri, L.Squassante, L.Ziviani, G.P.Ventresca
“Salmeterol and fluticasone propionate administered as a combination: lack of pharmacokinetic and pharmacodynamic interaction”. Eur. J. Clin. Pharmacology, 56, (11); 781-791, 2001 S. Kirby, S. Milleri, L. Squassante, G.P. Ventresca
“The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy volunteers”. Br. J. Clin. Pharmacology, 51 (2): 147-52, 2001 L. Ziviani, L. Da Ros, L. Squassante, S. Milleri, M. Cugola, L Iavarone
“Direct measurement of the anti-influenza agent zanamivir in the respiratory tract following inhaled administration”. Antimicrobial Agents and Chemotherapy 44(7): 1974-1976, 2000 Amy W. Peng, Stefano Milleri, Daniel S. Stein
“Evaluation of the readability of information sheets for healthy volunteers in phase-I trials”. Eur. J. Clin. Pharmacology; 56(5) Berto D. Peroni M. Milleri S. Spagnolo AG
“Enantiomeric disposition of inhaled, intravenous and oral (r,s)-albuterol in man - no evidence of enantioselective lung metabolism”. Br. J. Clin. Pharmacology, 49(1): 15-22, 2000 Jonathan Ward PhD, James Dow PhD, Nigel Dallow MSc, Paul Eynott BSc, Stefano Milleri MD and Pietro Ventresca MD
"Evaluation of personalty as a component of the healthy condition of volunteers participating in phase I studies". Eur. J. Clin. Pharmacology 51: 209-2013, 1996 D. Berto, S. Milleri, L. Squassante, P. Baroldi